Cardiorespiratory evaluation of juvenile rats experimentally envenomed with Tityus serrulatus venom
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چکیده
منابع مشابه
Cardiorespiratory evaluation of juvenile rats experimentally envenomed with Tityus serrulatus venom
Accidental envenomation caused by Tityus serrulatus scorpions is very common in Brazil and may result in serious cardiorespiratory alterations that are frequently fatal to children. In the present study, the effects of T. serrulatus venom on the cardiorespiratory system of recently weaned male Wistar rats were evaluated. Fifteen animals were distributed into three groups (n = 5). The control gr...
متن کاملHematological and biochemical profiles of rats submitted to experimental poisoning with Tityus serrulatus venom
The hematological and biochemical profiles of newly weaned rats submitted to experimental poisoning with T. serrulatus venom were evaluated. Fifteen recently weaned male Wistar rats (mean weight 130g) were distributed into three equal groups (n = 5). Animals in the control group (group A) received a subcutaneous injection of 400μL of ultra-pure water, while those in the experimental groups rece...
متن کاملElectrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom
Scorpions are among the oldest venomous living organisms and the family Buthidae is the largest and most medically relevant one. Scorpion venoms include many toxic peptides, but recently, a metalloprotease from Tityus serrulatus called antarease was reported to be capable of cleaving VAMP2, a protein involved in the neuroparalytic syndromes of tetanus and botulism. We have produced antarease an...
متن کاملEffect of toxin-g from Tityus serrulatus scorpion venom on gastric emptying in rats.
The effect of toxin-gamma from Tityus serrulatus scorpion venom on the gastric emptying of liquids was studied in 176 young adult male Wistar rats (2-3 months of age) divided into subgroups of 8 animals each. Toxin-gamma was injected i.v. at doses of 25, 37.5, 50 or 100 micrograms/kg and the effect on gastric emptying was assessed 30 min and 8 h later. A time-course study was also performed by ...
متن کاملAge effects on the pharmacokinetics of tityustoxin from Tityus serrulatus scorpion venom in rats.
The pharmacokinetics of scorpion venom and its toxins has been investigated in experimental models using adult animals, although, severe scorpion accidents are associated more frequently with children. We compared the effect of age on the pharmacokinetics of tityustoxin, one of the most active principles of Tityus serrulatus venom, in young male/female rats (21-22 days old, N=5-8) and in adult ...
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ژورنال
عنوان ژورنال: Journal of Venomous Animals and Toxins including Tropical Diseases
سال: 2010
ISSN: 1678-9199
DOI: 10.1590/s1678-91992010000200008